National Medical College is located at Birgunj, the headquarter of Parsa District and the second largest city of Nepal with a population of nearly . hundred thousand people. Situated on plain land, it is a most vibrant city, and has remained the Gateway of Nepal since its days of foundation in 1897 by Bir Shamsher J.B. Rana. Now it has become the hub of the commercial and industrial activities of the country and is quite close to the Indian Railway Station, Ruxaul Junction, about an hour's walk. It is a multicultural city where Hindus, Muslims, Sikhs, Buddhists and other ethnic communities live together in peace and harmony. Hindus and Muslims constitute the major portion of its population. It is a multilingual city, the residents of which speak Nepali, Bhojpuri, Hindi, Urdu, English, Newari and other local dialects. Places of worship like temples and mosques are to be found at short distances in the city.

Apart from the Indian railway, this city has good links of roads by which all the Indian Metropolitan cities have become quite accessible. Simra is the nearest Airport from where one can fly and arrive Kathmandu in a quarter of an hour. Likewise, Morning, Day and Night bus services are readily available to and from Kathmandu. As for the climate, it is temperate with 8 c. lowest in the winter and 37 c. highest in the summer and the average rain fall registered during the rainy season is 80mm. Nice hotels and shopping centers are to be found in the city. Royal Chitwan National Park is about 4hrs. drive from here where one can go to enjoy the wildlife of Nepal.